The radical overhaul, which encompasses 120 teachers, is part of an effort to comply with a federal mandate tied to funding.
But some school officials say the schools have undeserved reputations, and experts say huge staffing changes alone will not guarantee student improvement.
The Courier-Journal reports state education auditors earlier this spring, visited the 10 schools identified as the lowest-performing schools in Kentucky, including the six in Louisville.
In April, the U.S. Department of Education announced Kentucky would receive nearly $56 million through a federal school improvement grant program, to fix its persistently low-achieving schools.