The Woodburn, Plano, and Browning Volunteer Fire Departments were called to the scene of a home on Secretariat Drive around 11:30 Friday night.
The home was fully engulfed when fire fighters arrived.
Authorities say two firefighters were injured when a wall collapsed.
Firefighter James Beatie was treated and released at The Medical Center. Another fireman, 25-year-old Jeremy Vance, was transported to Vanderbilt Hospital. He has also been released.
A female, whose identity is being withheld, was pronounced dead at the scene.
An autopsy will be performed Saturday in Louisville by the State Medical Examiner's Office.
The cause of the fire is under investigation.