MUHLENBERG COUNTY, Ky. (WBKO) -- "Never dreamed anything like this would happen -- especially in my backyard," said Clarence Humphrey, a neighbor who woke up to sirens and saw flames outside his door.
The fire not only destroyed a home, but took several lives.
It started around two o'clock this morning on Motes Lane in Greenville.
"First responders were here in a matter of moments, and when they arrived, the house was fully engulfed," said Tpr. Stu Recke, from Kentucky State Police Post 3.
"I knew they weren't getting out. I just froze -- went numb really." Humphrey said.
Trooper Recke says one family of eleven was in the house when the the flames started -- only two made it out.
"Right now, our investigators are sifting through the residence, trying to locate the other four victims," Recke said.
One neighbor says he saw the father and one of the girls outside the two-bedroom house with burns before they were flown to Vanderbilt Hospital.
According to neighbors, the children's ages range from about four years old to young teens, and they often saw them riding bikes and playing outside -- a site they will miss.
"I'd sit over at the house and I'd pray a while and cry a while. I knew they weren't making it, and they didn't," Humphrey said, as tears fell down his face.
So far, the condition of the two in the hospital has not been released.
Police say they do not believe the cause of the fire is suspicious.
Keep checking back for the latest.