State Commerce Secretary Jim Host announced he is resigning.
The resignation will take effect October 14.
Host has been one of Governor Fletcher's closest advisers and defenders.
His resignation letter says his health and that of his wife factors in his decision.
Host has previously served as Fletcher's communications director during one of several times the position became vacant.
The special grand jury that has been investigating personnel practices of the Fletcher administration subpoenaed Host, but he declined to testify during his appearance.