Federal agents have uncovered a major medicare fraud operation.

Officials say it's the largest bust in recent history.

Attorney General Eric Holder says more than a hundred people are charged in the case.

Holder says, "We've charged 107 defendants in seven different cities for their alleged participation in medicare fraud schemes involving approximately $452 million in false billings. This is the highest amount of alleged false medicare billings involved in a single take down in the strike forces five year history."

Those accused include doctors, nurses, social workers, and health care company owners.